Profil Dr. Marselina Irasonia Tan

Dr. Marselina Irasonia Tan

Ph.D (Med.Uni Lübeck)


School of Life Sciences & Technology
Institut Teknologi Bandung
Jl. Ganesa No. 10 Bandung,
Indonesia 40132
Phone: +62 22 251 1575, 250 0258
Fax: +62 22 253 4107
Email: marsel@sith.itb.ac.id

Education
Associate Professor in Cell and Molecular Biology Institut Teknologi Bandung

2010

Doctorate (Molecular Biology) Medical University Lübeck

1998

Master (Biology) Institut Teknologi Bandung

1990

Bachelor (Biology) Padjajaran University

1986

Research Topic
  • Molecular process of tumorigenesis, metastasis, and angiogenesis as well as stem cell research
  • Natural bio-active compounds from Indonesia that can act as anti-cancer compounds
  • Cell differentiation process of stem cells
Courses Tought
Course Code Course Name
BI-4103 Imunologi
BI-5113 Biologi Kanker
BT-5012 Perancangan Penelitian Bioteknologi, Bioetika, dan Paten
BI-3111 Biologi Sel dan Molekul Terapan
BT5091 Penelitian Magister Bioteknologi I
BT-5214 Rekayasa Sel & Jaringan untuk Biomedik
BT-5216 Infeksi dan Imunitas
BI-2201 Perkembangan Hewan
BI-5012 Biologi Sel Lanjut
BE-3210 Rekayasa Kultur Sel Hewan
Publications
National Publications :

  1. Heryakusuma C, Puspasari F, Ihsanawati I, Giri-Rachman EA, Tan MI, Ramadhani E, Nurainy N, Natalia D. 2016. Cloning and Expression of Small Hepatitis B Surface Antigen (sHBsAg) In Hansenula polymorpha . Mikrobiologi Indonesia 10(4)
  2. Martgrita, M.M., Tan, M.I. (2016) Pengaruh estradiol-17β dan kolagen tipe IV terhadap ekspresi gen PIK3CA untuk menginduksi ekspresi c-erbB2 pada lini sel kanker ovarium SKOV-3. Jurnal Biologi Indonesia 12 (1): 59-66.
  3. Kurniatanty I, Tan MI,  Ruml T,  Sumarsono SH. 2015. Potensial cell proliferation inhibitor isolated from Indonesian brown algae (Phaeophyta).      International Journal of Pharmacy and Pharmaceutical Sciences 7(11): 140-143. ISSN- 0975-1491

International Publications :

  1. Winarto H, Tan MI, Sadikin M and Wanandi SI. 2017. ARID1A Expression is Down-Regulated by Oxidative Stress in Endometriosis and Endometriosis-Associated Ovarian Cancer. Translational Oncogenomics 9:1-7.
  2. Sanawati, A., Barlian, A., and Tan, M. I. Construction, in silico analysis, and in vitro expression of DNA vaccine candidate encoding human rotavirus capsid protein VP6. International Journal of Integrative Biology 18(1): 1-6.
  3. Rahmah, L., Rachman, E.G., Retnoningrum, D., and Tan, M.I. 2017. Molecular Characterization and Expression of Human Rotavirus Recombinant Protein VP2, VP6, and VP7 Transfected in Vero cell. International Journal of Integrative Biology 18(1): 7-12.
  4. Tan MI & Hayati 2017. Inhibition of Mammary Gland Cancer Development by Propolis and Mangostin in Female Mice Balb/C. J. Math. Fund. Sci., Vol. XX, No. X, 2017, 49(1): 40-50
  5. Zachariasova MS, Kurniatanty I, Gbelcovac H, Jirua M, Ruberta J, Nindhiad TGT, D’Acuntoc CW, Sumarsono SH, Tan MI, Hajslova J, and Ruml T. 2017. Bioprospecting of Turbinaria macroalgae as a potential source of health protective compounds. Chemistry & Biodiversity 14(2) (online)
  6. Herdwiani W, Soemardji AA, El-Fahmi, Tan MI. 2016. Gas Chromatograph spectrometer analysis and acute oral toxicity of Cinnamomum burmannii., Ness Ex.BL. essential oil. Asian Journal of Pharmaceutical and Clinical Research 9(3):240-245
  7. Herdwiani W, Soemardji AA, El-Fahmi, Tan MI. 2016. A Review of cinnamon as as a potent anticancer drug. Asian Journal of Pharmaceutical and Clinical Research. 9(3):8-13
  8. Tan, MI. 2016. Cell and molecular biology for diagnostic and therapeutic technology. Journal of Physics: Conference Series 694 (2016) 012001
  9. Kustiati, Marselina I. Tan, Sri Yusmalinar, Trisnowati B. Ambarningrum and Intan Ahmad. Monitoring Permethrin and Imidacloprid Resistance in Indonesian House Fly Musca domestica L. (Diptera: Muscidae). Journal of Entomology 2016: 13 (1-2): 40-47
  10. Ugiyadi, M., Tan , M. I., Giri-Rachman, E. A., Zuhairi, F.R., and Sumarsono S. H.. 2013. The expression of essential components for human influenza virus internalisation in Vero and MDCK cells. Cytobiotech, Published online: 04 August 2013.
  11. Zuhairi, F.R.,, Ugiyadi, and M., Tan , M. I. . 2012. The role of trypsin in the internalization process of influenza H1N1 virus into Vero and MDCK Cells. ITB Journal of Science , 4A: 297-307
  12. Rahayu, R., Ahmad, I., Ratna E.S., Tan, M.I ., and Hariani, N. 2012. Present status for carbamate, pyrethroids and phenylpyrazole insecticide resistance to German cockroach, Blatella germanica in Indonesia. Journal of Entomology , 9: 361-367.
  13. Tan, M.I. 2003. Effect of Sargassum Siliquosum extract on the expression of p53 and estrogen receptor on Breast Cancer Cell Line T47D and MCF7. Proceedings of International on Biomedicines 114-122

Proceeding:

  • Martgrita, M.M., Tan, M.I. (2015) The Role of Estradiol-17β and Type IV Collagen on the Regulation and Expression Level of c-Erbb2 RNA and Protein in SKOV-3 Ovarian Cancer Cell Line. XIII International Conference on Cancer Science and Therapy (ICCST 2015), Singapore; eISSN: 1307-6892.
  • Martgrita, M.M., Gunarta, I K., Tan, M.I. (2015) The Role of Estradiol-17β and Type IV Collagen on GPR55 Gene Expression that Contributed to Increase SKOV-3 Ovarian Cancer Cell Line Proliferation. International Conference on Biological, Civil and Environmental Engineering (BCEE-2015), Denpasar, Bali; ISBN: 978-93-84422-08-0.

International Seminars :

  1. Sanawati, A., Barlian, A., dan Tan, M. I. (2016): Preparation and caharcterization of a rotavirus DNA vaccine encapsulated in chitosan nanoparticles, International Seminar and Workshop on Nanobiotechnology, Bandung-Indonesia.
  2. Rahmah, L., Rachman, E.G., Retnoningrum, D., dan Tan, M.I. (2016): Expression and Characterization of VP2, VP6, and VP7 Rotavirus protein in mammalian cell, Asean Microbial Biotechnology Conferences, Bali-Indonesia.
  3. Tan, MI. BRD4 and NF-κB pathway in ovarian cancer cells. FK-UNPAD, The 4th. Bandung international Biomolecular Medicine Conference. 5-6 September 2016. Bandung, Indonesia
  4. Tan, MI. Identifying Challenges of Biosimilar Drug Development. Bioprocess & Technology and 2016. APAC Summit IBC Asia, Singapore
  5. Tan, MI. Brd4 function on NFkappaB pathway.The 6th Annual Basic Science International Conference. 2-3 Maret 2016. Malang Indonesia
  6. Tan, MI & F Roesl. 2016. Effect of oxidative stress (hypoxia) on important cytokine in innate immune response on E6, E7, E6/E7- HPV16- human immortalized keratinocytes cells. AMBC, Bali, Indonesia
  7. Martgrita, M.M., Tan, M.I. (2015) XIII International Conference on Cancer Science and Therapy (ICCST 2015) The Role of Estradiol-17β and Type IV Collagen on the Regulation and Expression Level of c-Erbb2 RNA and Protein in SKOV-3 Ovarian Cancer Cell Line. Singapore, 2015
  8. Isma Kurniatanty, Sony Heru Sumarsono & Marselina I.Tan . 2013. Preliminary study of anticancer activity from brown algae (Phaeophyta) extracts. International Seminar on Tropical Bioresources for Sustainable Bioindustry. ITB Bandung, 30–31 October 2013
  9. Maharani Ugayadi,  Marselina I Tan , Ernawati A Giri rahman, Fawzi R Zuhairi, Sony H Sumarsono. Primary monkey trachea cell culture express the subtantial components for influenza virus internalization. International Seminar on Tropical Bioresources for Sustainable Bioindustry. ITB Bandung, 30–31 October 2013

National Seminar :

  • Sanawati, A., Barlian, A., dan Tan, M. I. (2016): Kloning dan karakterisasi in silico gen VP6 dari rotavirus G1P[8], Seminar Nasional Biologi USU, Medan-Indonesia.
  • Rahmah, L., Rachman, E.G., Retnoningrum, D., dan Tan, M.I. (2016): Kloning dan Karakterisasi Molekular Gen VP2 dan VP7 dari Rotavirus RV4 (G1P[8], Seminar Nasional Biologi USU, Medan-Indonesia.

Books

  1. Marselina I. Tan & Anggraini Barlian & Ernawati GR : BIOLOGI SEL DAN TERAPANNYA. Penerbit ITB 2015
  2. Marselina I. Tan. Karsinogenesis oleh Bahan Kimia. Basic Science of Oncology-Ilmu Onkologi Dasar. Perhimpunan Onkologi Indonesia 2010
  3. Marselina I. Tan. Hormon dan enzim pada kanker. Basic Science of Oncology-Ilmu Onkologi Dasar. Perhimpunan Onkologi Indonesia 2010
  4. Marselina I. Tan. Onkogen. Basic Science of Oncology-Ilmu Onkologi Dasar. Perhimpunan Onkologi Indonesia 2010

Patent:

  • Anggota dalam Tim. Kit Diagnostik Untuk Mendeteksi Infeksi Virus Hepatitis B Menggunakan Antibodi Primer lgY Anti Hepatitis B Surface Antigen (HBsAg) dan Antibodi Sekunder Monoklonal Anti-HBsAG Yang Terkonjugasi Horseradish Peroxidase (HRP) dan Proses Pembuatannya. 2018. P00201800256

Judul tulisan

Tahun

Diterbitkan sebagai:

 • Tan M.I. and B. N. E. Sophianie. The effects of mangostin on the activity of protein kinase A and expression of estrogen receptor in human breast cancer cell line MCF-7

2011

International conference Proceedings of PSRC – International conference on Management, Social Sciences, Biology & Pharmaceutical Sciences 2011
 • Tan, M.I. Hormon dan enzim pada kanker.

2008

The 12th Course & Workshop Basic Science of Oncology Modul B. Januari 2008.
 • Tan, M.I & Agustina, S. 2008. The Effect of Estradiol-17b on The Expression of VEGF and ER Genes Breast Cancer Cell Line MCF-7 Cultured on Type IV Collagen.

2008

The 1st International Symosium on molecular pathogenesis. Bandung, January 2008.
 • Tan, M.I & Sophianie, N.E. 2007. The effect of mangostin on the activity of protein kinase A and the existence of estrogen receptor protein in human breast cancer cell line MCF-7.

2007

International Seminar on Pharmaceutics. Bandung, October 31-November 1, 2007.
 • Tan, M.I & Warjoto, R.E. The effect of dichloromethane Extract of Phyllanthus Amarus Schum Et. Thonn. on ERK 1/2 Expression in Mouse Mammary Cancer Cell Line, MMT 060562.

2007

International Seminar on Pharmaceutics. Bandung, October 31-November 1, 2007.
 • Tan, M.I & Fuad D.G.. The effect of dichloromethane extract of Phyllanthus amarus Schum. et Thonn on apoptosis of mouse mammary cancer cell line MMT 060562 through the caspase-3 activity.

2007

International Seminar on Pharmaceutics. Bandung, October 31-November 1, 2007.
 • Tan, M.I. Onkogen

2007

The 11th Course & Workshop Basic Science of Oncology Modul A. Mei 2007
 • Tan, M.I., Velaneta, Haga, S.and S.Imai. Effect of fucoidan and Sargassum siliquosum J. Agardh extract on the expression of ERK1/2 in breast cancer cell line MCF-7.

2006

Meeting of society of research of Phytochemical. Nagoya, Japan. November 2006
 • Tan, M.I., Velaneta, Haga, S.and S.Imai.Effect of fucoidan and Sargassum siliquosum J. Agardh extract on the expression of ERK1/2 in breast cancer cell line MCF-7.

2006

Association of basic investigation of breast carcinoma.

Chiba PrefectureJapan. July 2006

 • Tan, M.I. and Sulistyawati, D.R.The effect of fucoidan and Sargassum siliquosum J. Agard extract on the existence of caspase 9 protein in MCF-7 human breast cancer cell line. ICMNS-ITB
2006
ICMNS-ITB, Bandung, November 2006
 • Tan, M.I. and Wiryanto, A. The Effects of Estradiol-17β on ERK1/2 Expression in MCF-7 Breast Cancer Cell Line.

2006.

ICMNS-ITB, Bandung, November 2006
Professional Memberships
  • Society for Medicinal Plant Research – Gesellschaft fuer Arzneiplanzenforschung
  • Asosiasi Sel Punca Indonesia (Indonesian stem cell association)
  • Perhimpunan Ahli Anatomi Indonesia (Indonesian anatomy experts association)
International Training
1990- internship as JSPS (Japan Society for Promoting Science) scholar –  in  Dep of Obstetrics and Gynecology – School of Medicine- Nagoya University, Japan
2012-2013 Visiting Scientist as Fulbright scholar- in Kansas University Medical Center, Kansas USA
2013 (Oct) – 2014 (Jan) Guest Scientist as DAAD (Deutsche Akademische Austauschdienst) scholar – in German Cancer Research Center, Heidelberg-Germany
Research Grant (as Principal Investigator)
  1. Sistem Pencitraan Gelombang Mikro Untuk Deteksi Dini Kanker Payudara: Proof-Of-Concept & Phantom Validation. RISET ITB. 2018
  2. Sistem analisis pengenalan gambar kromosom pada darah. Penelitian Terapan Unggulan Perguruan Tinggi-Riset DIKTI. 2018
  3. Produksi HBsAg dan Anti-HBsAg Untuk Pengembangan serta Komersialisasi Kit Diagnostik Hepatitis B Indonesia. Rispro LPDP. 2016-SEKARANG
  4. Pengembangan dan pengujian efek antikanker nanopartikel BRD4-inhibitor-jakalin-kitosan secara in vitro pada lini sel kanker ovarium dan payudara       Riset dan Inovasi KK-ITB 2016/2017
  5. Analisa Profil Exosome pada Urine dan Darah penderita prediabetes di sekitar Bandung sebagai Upaya Identifikasi Kandidat Biomarker Prediabetes Nutrifood Research Grant 2016
  6. Produksi conditioned medium sel punca mesenkim (human adipose tissue derived mesenchymal stem cells-conditioned medium) sebagai bahan antiaging: Pembuatan karyotyping stem cell. Program Insentif Riset Sistem Inovasi Nasional 2016
Project/Consultancy Experiences
  • Consultant in Cell Culture. Sanbe Farma, Indonesia (2000-2005)
  • Consultant in Cell Culture. Biofarma Indonesia (2006-2010)
  • Consultant in Stem Cell Culture. Rajawali Hospital, Indonesia (2009-2012)
EnglishIndonesia