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SONY HERU SUMARSONO, M.Sc., Ph.D.

Associate Professor
Physiology, Animal Development, and Biomedical Sciences
School of Sciences and Technology
Institut Teknologi Bandung
sonyheru@itb.ac.id
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OVERVIEW

Sony Heru Sumarsono, M.Sc., Ph.D.mainly focuses in animal development and physiological sciences especially in embryo development, abnormalities and syndromes in development, as well as degenerative diseases. Over the years Dr. Sony has published multitude of studies on development and physiology involving algae and primarily animals. In the recent years, he is researching and uncovering characterisation of Insulin-like Growth Factor 3 of Cyprinids and the identifying gene roles in mammalian embryo implantation process along with their interactions with Areca palm extract.

Year Institution Program Notes
1996 Monash University, Australia Molecular Genetic and Development. Doctoral
1989 Monash University, Australia Molecular Embryology and Birth Defects. Master
1986 Universitas Gadjah Mada, Indonesia Embryology Bachelor
Year Publications
2024 Suryohastari, R. R. B.; Sumarsono, S. H.; Giri-Rachman, E. A.; Edi, S. P. 2024. Intravaginally CpG-ODN and Salmonella enteritidis on TLR21, cytokines, and AvBD10 gene expressions in the reproductive tract of native chicken. Tropical Biomedicine, 41(2): 156–167, DOI: 10.47665/tb.41.2.002
2024 Suryohastari, R. R. B., Sumarsono, S. H., Giri-Rachman, E. A., Edi, S. P., Sukoco, R., & Wicaksana, D. N. (2024). Microbial Count and AvBD10 Expressions in Ovaries and Oviducts of Kampung Unggul Balitbangtan (KUB)-1 Chickens Following Intravaginally CpG-ODN and S. Enteritidis. Journal of Tropical Biodiversity and Biotechnology, 9(2), 88750.
2023 Ruyani, S. F., & Sumarsono, S. H. (2023). Exposure to Valproic acid (VPA) resulted in alterations in the expression of angiogenic genes (NRP-1, VEGFA, VEGFR-2 and sFlt1) and histological modifications in the placenta of mice (Mus musculus). Reproductive Toxicology, 119, 108405.
2022 Rachma, S., Madihah, M., & Sumarsono, S. H. (2022). Spatiotemporal Profile of Skeletal Development in Bonylip Barb, Osteochilus vittatus (Valenciennes, 1842). Asian Fisheries Science, 35(4).
2021 Madihah, M., Andriani, S., Nisa, S. A. R., Wibowo, I., & Sumarsono, S. H. (2021). Reproductive performance and vitellogenin gene expression on female Bonylip barb (Osteochilus vittatus) during its reproductive cycle under culture conditions. Agriculture and Natural Resources, 55(4), 557-568.
2021 Yulianti, A. B., Sumarsono, S. H., Ridwan, A., & Yusuf, A. T. (2021). Protofibril formation: decreased total glutathione concentration as an early indicator of neuron damage in the brainstems of Wistar rats treated with rotenone. F1000Research, 10, 1158.
2021 Safitri, F. A., Tu, A. T. T., Hoshi, K., Shobo, M., Zhao, D., Witarto, A. B., Sumarsono, S. H., Giri-Rachman, E. A., Tsukakoshi, K., Ikebukuro, K., & Yamazaki, T. (2021). Enhancement of the immunostimulatory effect of phosphodiester CPG oligodeoxynucleotides by an antiparallel Guanine-Quadruplex structural scaffold. Biomolecules, 11(11), 1617. https://doi.org/10.3390/biom11111617
2020 Widyastuti, R., Prastowo, S., Sumarsono, S. H., Lubis, A., Hartady, T., Syamsunarno, M. R., & Sudiman, J. (2020). Deleterious effect of short-term gavage of an ethanol extract of cogon grass (Imperata cylindrica L.) roots on testis and epididymal sperm quality. Veterinary World, 13(7), 1311.
2020 Wibowo, I., Nasution, F. R., Taufik, I., Zain, R. S., Marlinda, N., Utami, N., et al., & Sumarsono, S. H. (2020). Anti-inflammatory activity of Indonesian propolis in Zebrafish (Danio rerio) larvae. Journal of Food and Nutrition Research, 8(5), 225-230.
2018 Eriani, K., Boediono, A., Sumarsono, S. H., & Azhar, A. (2018). Utilization of Oocytes Collected from Preserved Ovarian for In Vitro Production of Cat Embryos. Biosaintifika: Journal of Biology & Biology Education.
2017 Stranska-Zachariasova, M., Kurniatanty, I., Gbelcova, H., Jiru, M., Rubert, J., Nindhia, T.G.T., D’Acunto, C.W., Sumarsono, S.H., Tan, M.I., Hajslova, J., Ruml, T. (2017). Bioprospecting of Turbinaria Macroalgae as a Potential Source of Health Protective Compounds. Chemistry and Biodiversity, 14(2), e1600192.
2017 Wahyuni, F., & Sumarsono, S. H. (2017). Pengaruh Linamarin terhadap Penampilan Reproduksi Induk Mencit (Mus musculus L.). Jurnal Ipteks Terapan.
2016 Widyastuti, R., Lesmana, R., Boediono, A., & Sumarsono, S. H. (2016). Effect of cryoprotectants on sperm vitrification. Advances in Biomolecular Medicine: Proceedings of the 4th BIBMC and the 2nd ACMM, Bandung, Indonesia.
2016 Widyastuti, R., Sumarsono, S. H., Boediono, A., & Rasad, S. D. (2016). Low concentration of ethylene glycol improved recovery rate of human spermatozoa after vitrification. Jurnal Veteriner.
2015 Kurniatanty, I., Tan, M.I., Ruml, T., & Sumarsono, S.H. Potential cell proliferation inhibitor isolated from Indonesian brown algae (Phaeophyta). International Journal of Pharmacy and Pharmaceutical Sciences, 7(11), 140-143.
2015 Candramila, W., Sumarsono, S.H., Suryobroto, B., & Moeis, M.R. Face Shape Variation Among Sundanese People from Western Java, Indonesia. HAYATI Journal of Biosciences, 22(1), 34-40.
2015 Yulianti, A. B., Sumarsono, S. H., Ridwan, A., & Yusuf, A. T. (2015). Hubungan Reactive Oxygen Species (ROS), Superoxide Dismutase (SOD) dengan Protein α-Sinuklein-Larut Air pada Batang Otak Tikus yang Diinduksi Rotenon. Global Medical & Health Communication.
2014 Ugiyadi, M., Tan, M.I., Giri-Rachman, E.A., Zuhairi, F.R., & Sumarsono, S.H. The expression of essential components for human influenza virus internalisation in Vero and MDCK cells. Cytotechnology, 66(3), 515-523.
2013 Eriani, K., Sukra, Y., Boediono, A., Djuwita, I., & Sumarsono, S. H. Produksi embrio kucing secara in vitro dari spermatozoa hasil preservasi melalui fertilisasi mikro. Jurnal Kedokteran Hewan.
2013 Ugiyadi, M., Zuhairi, F. R., Tan, M., & Sumarsono, S. H. (2013). Influenza H1N1 Virus Internalization in Vero and MDCK Cell Lines. 6th International Singapore Symposium of Immunology, DOI:10.13140/RG.2.2.36772.17283
2007 Sumarsono, S. H. (2007). Identifikasi protein yang berperan dalam perkembangan abnormal embrio mencit akibat terdedah teratogen (Asam metoksiasetat – MAA). Seminar Patologi Eksperimental, Dep. Patologi Anatomi FKUI Salemba-Jakarta, 1 Maret 2007.
2006 Madihah, Kusumaningtyas, H., Boediono, A., & Sumarsono, S. H. (2006). Kualitas, kemampuan implantasi dan viabilitas in vivo embrio mencit (Mus musculus) Galur Swiss Webster setelah pembekuan dengan metode vitrifikasi. Biota, XI(2), 72-79.
2005 Ruyani, A., Sudarwati, S., Sutasurya, L.A., Sumarsono, S.H., Kim, D.J., & Chung, J.H. (2005). A teratoproteomics analysis: Heat shock protein 70 is upregulated in mouse forelimb bud by methoxyacetic acid. Birth Defects Research (Part A), 73, 517-521.
2005 Sumarsono, S. H. (2005). Identifikasi fetus trisomy 16 pada mencit sebagai hewan model untuk kasus Down syndrome. Kongres dan Pertemuan Ilmiah Nasional Perhimpunan Ahli Anatomi Indonesia, FK-UGM Jogjakarta, 29-30 Juli 2005.
2005 Sumarsono, S.H., Widjaja, L.K., Kusumaningtyas, H., Barlian, A., & Tan, M.I. (2005). The Development of exencephaly in mouse embryo caused by the methoxyacetic acid treatment, an histological analysis. Second International Seminar on Environmental Chemistry and Toxicology, Novotel Hotel Yogyakarta, 26-27 April 2005.
2004 Kaiin, E.M., Sumarsono, S.H., Surjono, T.W., & Sudarwati, S. (2004). Maternal contribution in revealing the effects of methoxyacetic acid (MAA) administered before implantation on the embryonic development of Swiss Webster mice (Mus musculus). Annales Bogorienses, n.s. 9(1), 20-26.
2003 Ruyani, A., Sudarwati, S., Sutasurya, L.A., Sumarsono, S.H., & Gloe, T. (2003). The Laminin Binding Protein p40 Is Involved in Inducing Limb Abnormality of Mouse Fetuses as the Effects of Methoxyacetic Acid Treatment. Toxicological Sciences, 75, 148-153.
2002 Sumarsono, S.H., Koesoemohamidjojo, K.A., & Kusumaningtyas, H. (2002). Death at birth of Swiss Webster mouse fetuses causing immature development of the lung after treated with methoxyacetic acid (MAA). Indon. J. Environ. Chem. Toxicol., 1(2), 30-34.
2002 Sumarsono, S. H., Ibrahim, M., & Sudarwati, S. (2002). The effect of methoxyacetic acid (MAA) and MAA-treated internal uterine environment on the quality of Swiss Webster mouse preimplantation embryo and their viability on postimplantation stage. Reprotech, 2, 97-101.
2001 Ruyani, A., Sudarwati, S., Sutasurya, L.A., & Sumarsono, S.H. (2001). Protein yang terkait dengan teratogenisitas anggota tubuh mencit Swiss Webster akibat perlakuan dengan asam metoksiasetat (MAA). Proc. ITB, 33(3), 81-86.
2001 Sumarsono, S. H., Sudarwati, S., & Kaiin, E. M. (2001). Asam Metoksiasetat (MAA) menurunkan kualitas dan kemampuan implantasi embrio mencit Swiss Webster langsung maupun tidak langsung. Prosiding Seminar MIPA 2000, FMIPA-ITB, 158-167.
2001 Sumarsono, S. H., Adelina, M., & Kusumaningtyas, H. (2001). Asam Metoksiasetat terbukti menurunkan kualitas embrio Mencit Swiss Webster tahap praimplantasi. Hayati, 8(3), 62-65.
2001 Ruyani, A., Sudarwati, S., Sutasurya, L.A., & Sumarsono, S.H. (2001). Perubahan Profil Protein tunas Anggota tubuh depan mencit (Mus musculus) Swiss Webster akibat perlakuan dengan asam metoksiasetat (MAA). Medika, Jurnal Kedokteran dan Farmasi, 6, 363-367 (tahun XXVII).
2000 Sumarsono, S.H., & Kola, I. (2000). Pembuatan mencit chimaera trisomy 16-diploid sebagai hewan model Down syndrome mosaik. Prosiding Seminar Nasional LUSTRUM ke IX Fakultas Biologi UGM, Yogyakarta, 22 September 2000, 330-346.
2000 Sumarsono, S. H. (2000). Horison: Teknologi Rekombinasi homologous untuk membuat mencit dengan mutasi gen. Medika, Jurnal Kedokteran dan Farmasi, edisi 12, 794-799.
2000 Purwantini, E., Sumarsono, S. H., Adi, T. P., & Noer, A. S. (2000). Perkembangan Bioteknologi Molekul dan aplikasinya. Proceedings Institut Teknologi Bandung, Suplemen 32(2), 237-297.
2000 Sumarsono, S. H. (2000). Horison: Teknologi Mencit Chimaera. Medika, Jurnal Kedokteran dan Farmasi, edisi 9, 581-587 (September 2000).
1998 Drago, J., Padungchaichot, P., Wong, J.Y.F., Lawrence, A.J., McManus, J.F., Sumarsono, S.H., Natoli, A.L., Lakso, M., Wreford, N., Westphal, H., Kola, I., & Finkelstein, D.I. (1998). Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site specific recombination. Journal of Neuroscience, 18(23), 9845-9857.
1998 Sumarsono, S.H., Kusumaningtyas, H., Mori, N., Sumida, H., Yasuda, M., Soerjono, T.W., & Sudarwati, S. (1998). The over expression of Ets2 gene during abnormal mouse forelimb development affected by methoxyacetic acid. Indonesia Toray Science Foundation Seminar, Jakarta Hilton, 11 February 1998.
1998 Sumarsono, S. H. (1998). HIV dan mekanisme hancurnya sistem kekebalan tubuh. Medika, Jurnal Kedokteran dan Farmasi, No. 10/XXIV, Oktober 1998.
1997 Iannello, R.C., Young, J., Sumarsono, S.H., Tymms, M., Dahl, H-H.M., Gould, J., Hedger, M., & Kola, I. (1997). Regulation of Pdha-2 expression is mediated by proximal promoter sequences and CpG methylation. Molecular and Cellular Biology, 17(2), 612-619.
1996 Sumarsono, S.H., Wilson, T.J., Tymms, M., Venter, D.J., Corrick, C.M., Kola, R., Lahoud, M., Papas, T.S., Seth, A., & Kola, I. (1996). Down syndrome-like skeletal abnormalities in Ets2 transgenic mice. Nature (London), 379, 534-537.
1996 Kola, I., & Sumarsono, S.H. (1996). Microinjection of in vitro transcribed RNA and antisense oligonucleotides in mouse oocytes and early embryos to study gain- and loss-of function of genes. Molecular Technology, 6, 191-199.
1995 Hwang, S.Y., Hertzog, P.J., Holland, K.A., Sumarsono, S.H., Tymms, M.J., Hamilton, J.A., Whitty, G., Bertoncello, I., & Kola, I. (1995). Homozygous null mutation in the gene encoding a type I interferon receptor component eliminates antiviral and antiproliferative responses to interferon α and β and alters macrophage response. Proc. Natl. Acad. Sci. USA, 92, 11284-11288.
1995 Kola, I., & Sumarsono, S.H. (1995). Microinjection of in vitro transcribed RNA and antisense oligonucleotides in mouse oocytes and early embryos to study gain and loss of function of genes. In: In vitro Transcription and Translation Protocols. Humana Press Inc., Totowa, New Jersey, 135-149.
1995 Kola, I., Christiano, F., de Haan, J.B., Thomas, R., Sumarsono, S., Corrick, C.M., & Tymms, M. (1995). Genes, Embryogenesis and Down syndrome. In: Advances in Human Reproduction (Moeloek, F.A., Affandi, B., Trounson, A.O., Eds.). The Parthenon Publishing Group, New York, 309-320.
1995 Iannello, R.C., Young, J., Sumarsono, S.H., Tymms, M., & Kola, I. (1995). A model for understanding gene regulation during spermatogenesis: The mouse Pdha-2 promoter. Reprod. Fertil. Dev., 7, 705-712.
1994 Iannello, R.C., Young, J., Sumarsono, S., Tymms, M., & Kola, I. (1994). Mouse testis Pdha-2 promoter upstream sequences confer tissue- and temporal-specific activity in transgenic mice. Reprod. Fertil. Dev., 6(40), 599-604.
Year Patent
2013 Over Ekspresi Gen α2,6 Sialiltransferase Macaca fascicularis pada Sel Vero. Nomor Permohonan: P00201300277
Year Research Funding
2020 EFEK APLIKASI AGEN IMUNOTERAPI SECARA INTRANASAL UNTUK MENINGKATKAN PRODUKSI SITOKIN PENEKAN ALERGI [SITH.PN-1-31-2020]
2020 Kajian Pola Ekspresi Gen Insulin-like Growth Factor 3 (Igf3) secara Spasial dan Temporal pada Ikan Nilem (Osteochilus vittatus Valenciennes, 1842)
2020 KARAKTERISASI PARSIAL DAN POLA EKSPRESI GEN VITELLOGENIN PADA IKAN NILEM (OSTEOCHILUS HASSELTI) SELAMA FASE REPRODUKSI [SITH.PN-1-30-2020]
2020 POTENSI EKSTRAK AKAR ALANG-ALANG (Imperata cylindrical) SEBAGAI ANTIFERTILITAS PADA MENCIT JANTAN
2022 Kegiatan Lanjutan Peningkatan Kapasitas Pengajar Politeknik Negeri Nusa Utara, Kepaulan Sangihe melalui Kunjungan Pengajaran Dosen-Dosen Kelompok Keilmuan (KK) Fisiologi Perkembangan Hewan dan Sains Biomedika (FPHSB) SITH ITB
2022 PENGARUH ASAM VALPROAT (VPA – OBAT ANTI-EPILEPSI) TERHADAP EKSPRESI GEN NEUROPILIN -1 (NRP-1) DAN ANGIOGENESIS PADA PLASENTA MENCIT (MUS MUSCULUS L.) [LPPM.PN-1-89-2022]
2022 Peningkatan Kapasitas dan Kualitas Politeknik Negeri Nusa Utara, Kepulauan Sangihe melalui Kunjungan Pengajaran oleh Dosen-Dosen KK Fisiologi, Perkembangan Hewan, dan Sains Biomedika SITH ITB
2023 STUDI EFEK KOPI ROBUSTA (COFFEA CANEPHORA) UNTUK PENCEGAHAN GANGGUAN MEMORI MELALUI ANALISIS PERILAKU DAN EKSPRESI GEN PADA HIPOKAMPUS TIKUS (RATTUS NORVEGICUS) MODEL PENYAKIT ALZHEIMER [SITH.PPMI-1-19-2023]
2024 DAMPAK ASAM VALPROAT TERHADAP EKSPRESI GEN YANG TERLIBAT DALAM PROSES NEURULASI EMBRIO MENCIT [SITH.PPMI-1-22-2024]
2024 MEMBANGUN KESEHATAN GENERASI MENDATANG MELALUI DISEMINASI PENGETAHUAN KESEHATAN REPRODUKSI PADA MASYARAKAT DALAM MENCEGAH STUNTING BALITA DI KABUPATEN SUMEDANG, JAWA BARAT
Year Title Leader Member
2024 MEMBANGUN KESEHATAN GENERASI MENDATANG MELALUI DISEMINASI PENGETAHUAN KESEHATAN REPRODUKSI PADA MASYARAKAT DALAM MENCEGAH STUNTING BALITA DI KABUPATEN SUMEDANG, JAWA BARAT [SITH.PPMI-2-04-2024] Sony Heru Sumarsono
2025 PAPARAN BAHAN BERBAHAYA DAN DAMPAKNYA TERHADAP KESEHATAN REPRODUKSI DAN PERKEMBANGAN ANAK [SITH.PPMI-2-12-2025] Ayda Trisnawaty Yusuf Sony Heru Sumarsono; Marselina Irasonia Tan; Anggraini Barlian; Lulu Lusianti Fitri; Indra Wibowo; Wardono Niloperbowo; Shanty Rahayu Kusumawardani; Noviana Vanawati; Rika Wahyuningtyas; Antonius Christianto
2025 KESEHATAN IBU DAN ANAK, DI KELURAHAN CIPAMEUNGPEUK, KECAMATAN SUMEDANG SELATAN, KABUPATEN SUMEDANG [SITH.PPMI-2-13-2025] Sony Heru Sumarsono
Year Location Programme Notes
Year Institution Position
Year Organization’s Name Role/Position
2006 School of Life Sciences and Technology (SITH), ITB Member of Postgraduate Program Commission
2006 – 2007 School of Life Sciences and Technology (SITH), ITB Head of Research Group for Physiology, Developmental Biology, and Biomedical Science
2005 – 2010 School of Life Sciences and Technology (SITH), ITB Secretary of Senate
2006 School of Life Sciences and Technology (SITH), ITB Member of the 2008 Curriculum Development Team
2006 School of Life Sciences and Technology (SITH), ITB Committee Member for New Student Admission (Master’s and Doctoral Programs, 2006 Batch)
2006 School of Life Sciences and Technology (SITH), ITB Head of Institutional Development Study, Ad Hoc Committee for Strategic Plan Norms
2006 School of Life Sciences and Technology (SITH), ITB Coordinator of Institutional Development Study, Strategic Plan Review Team
Academic Year Course Name
2024/2025 Plant and Livestock Science
2024/2025 Biology A
2024/2025 Publication A
2024/2025 Evolutionary Biology: Concepts and Applications
2024/2025 Systems Biology
2024/2025 Special Topics in Degenerative Diseases
2024/2025 Reproductive Biotechnology
2025/2026 Animal Development (K01)
Year Description Note Organizer Location Category
(National/
International)