Information on the insecticide resistance profiles of Aedes aegypti in Indonesia is fragmentary because of the lack of wide-area insecticide resistance surveillance. Prof. Intan Ahmad, Ph.D. and his colleagues collected Ae. aegypti from 27 Indonesian provinces and used WHO bioassays to evaluate their resistance to deltamethrin, permethrin, bendiocarb, and pirimiphos-methyl. The Ae. aegypti from all locations exhibited various levels of resistance to pyrethroids. Their resistance ratio to permethrin and deltamethrin ranged from 4.08× to 127× and from 4.37× to 72.20×, respectively. Most strains from the highly urbanized cities on the island of Java exhibited low to moderate resistance to pyrethroids. The strains collected from the less populated Kalimantan region exhibited very high resistance to pyrethroids. Low levels of resistance to bendiocarb (RR50, 1.24–6.46×) and pirimiphos-methyl (RR50, 1.01–2.70×) were observed in all tested strains, regardless of locality. PBO and DEF synergists significantly increased the susceptibility of Ae. aegypti to permethrin and deltamethrin and reduced their resistance ratio to less than 16×. The synergism tests suggested the major involvement of cytochrome P450 monooxygenases and esterases in conferring pyrethroid resistance.

Article Citation:
Silalahi, C.N., Tu, W.-C., Chang, N.-T., Singham, G.V., Ahmad, I., Neoh, K.-B. (2022). Insecticide Resistance Profiles and Synergism of Field Aedes aegypti from Indonesia. PLoS Neglected Tropical Diseases; 16(6): 1-13. https://doi.org/10.1371/journal.pntd.0010501

Image:
Prof. Intan Ahmad, Ph.D. Profile Picture
(Source: https://sith.itb.ac.id/en/prof-intan-ahmad/)

https://mediakom.kemkes.go.id/2022/03/nyamuk-nyamuk-yang-berbahaya/

Profile of Prof. Intan Ahmad, Ph.D.:
https://sith.itb.ac.id/en/prof-intan-ahmad/