The SARS-CoV-2 Mpro Dimer-Based Screening System : A Synthetic Biology Tool for Identifying Compounds with Dimerzation Inhibitory Potential
This study by Ernawati Arifin Giri-Rachman, Ph.D., Azzania Fibriani, M.Si., Ph.D., and their colleagues aimed to develop a novel SARS-CoV-2 main protease (Mpro) dimer-based screening system (DBSS) utilizing synthetic biology in Escherichia coli BL21(DE3). We linked the SARS-CoV-2 Mpro with the DNA-binding domain of AraC regulatory protein, which regulates the reporter gene expression. Protein modeling […]